Product Details
| Product Name:
Ipramidil |
CAS No.:
83656-38-6 |
| Supply Ability:
10g |
Release date:
2026/04/20 |
Product Introduction
Bioactivity
| Name | Ipramidil |
| Description | Ipramidil (C80-1324) reveals marked dilator activity in the coronary circulation of isolated working hearts. |
| In vitro | The vasodilator action of Ipramidil on coronary vessels is more potent than that of glyceryl trinitrate (GTN) and appears to be biphasic. The increase in coronary flow caused by furoxans as well as by GTN is blunted upon the confusion of the guanylate cyclase inhibitor methylene blue. NO sign of tachyphylaxis of the vasodilator response is seen upon the repeated or continuous (60 min) application of Ipramidil at a concentration of 1 μg/mL, which induces an increase in the coronary flow of 67±9%. Moreover, the vasodilator effect of Ipramidil is not different from control when Ipramidil is given after a 60 min preinfusion of 10 μg/mL GTN, i.e. under conditions of nitrate tolerance. However, when GTN is applied after a 30 min infusion of Ipramidil, its dilator response is significantly diminished. Unlike GTN, Ipramidil concentration independently increases the spontaneous beating rate of the hearts by 10-30 beats per minute and appeared to have a weak positive inotropic effect. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Ipramidil |
| Inhibitors Related | LY83583 | Lificiguat | Sinitrodil | NPR-C activator 1 | Riociguat | Nelociguat | Nitroprusside disodium dihydrate | NS-2028 | Indusatumab | Methylene Blue | Methylene Blue trihydrate | Cinaciguat |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$2500.00
|
VIP2Y
|
TargetMol Chemicals Inc.
|
2025-08-22 |
United States