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Postion:Product Catalog >iRGD peptide
iRGD peptide
  • iRGD peptide

iRGD peptide NEW

Price $72 $297 $513
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-05-26

Product Details

Product Name: iRGD peptide CAS No.: 1392278-76-0
Purity: 98.77% Supply Ability: 10g
Release date: 2026/05/26

Product Introduction

Bioactivity

NameiRGD peptide
DescriptioniRGD peptide (c(CRGDKGPDC)) is a 9-amino acid cyclic peptide (sequence: CRGDKGPDC) and a molecular mimicry agent that was originally identified in an in vivo screening of phage display libraries in tumor-bearing mice.
In vitroiRGD peptide-mediated tumor penetration involves a three-step process: initial binding to αv-integrins present on tumor vasculature or cells, the revelation of a C-terminal motif capable of binding to neuropilin-1 (NRP-1) through proteolysis, and subsequent cell internalization. Incorporation of the iRGD peptide into the ICOVIR15K fiber's C terminus specifically improves binding and internalization in MCF7 cells, known to express NRP-1 and integrins, without affecting the virus's ability to infect and replicate[1]. Alone, the iRGD peptide does not significantly impact gastric cancer cells. However, when combined with 5-FU, it notably enhances the chemotherapy's efficacy against gastric cancer cells via NRP1, at a concentration of 0.3 μmol/mL[2].
In vivoiRGD inserted in the oncolytic adenovirus ICOVIR15K (ICOVIR15K-iRGD) enhances early adenovirus dissemination through the tumor mass and elevates the antitumor effect in mice[1]. In vivo, iRGD did not alter the normal organ transduction pattern, with liver and spleen as main targeted organs. iRGD (4 mmol/kg, i.v.) combined with 5-FU significantly suppresses tumor growth in nude mice bearing human gastric cancer cells[2].
StorageKeep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : Insoluble
H2O : < 1 mg/mL (insoluble), Sonication is recommended.
KeywordsiRGD peptide | Integrin | Inhibitor | inhibit
Inhibitors RelatedK34c hydrochloride | Cucurbitacin B | Tirofiban hydrochloride monohydrate | (R)-Leucic acid | Lifitegrast | Cyclo(-RGDfK) | ADH-503 | Elsibucol | CLT-28643 | Bestatin hydrochloride | Gantofiban | 2-hydroxy Flutamide
Related Compound LibrariesCysteine Covalent Library | Macrocyclic Compound Library | Cyclic Peptide Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Peptide Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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