Product Details
| Product Name:
Izuforant |
CAS No.:
1429374-83-3 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | Izuforant |
| Description | Izuforant (JW1601) (Compound 24) exhibits potent anti-inflammatory and anti-pruritic activities, with a binding affinity for human serotonin 3 receptor (h5-HT3R) and an IC50 value of 9.1 μM. It is also an orally active antagonist of histamine H4 receptor (H4R), showing an IC50 value of 36 nM against human H4R [1] [2]. |
| In vitro | Izuforant (JW1601) (Compound 24) exhibits metabolic stability, with clearance rates (CL h,int) of 3.05 mL/min/mg in mice and 1.33 mL/min/mg in humans, indicating efficient metabolism across these species [1]. |
| In vivo | Izuforant (JW1601) administered orally at a dosage of 50 mg/kg once, effectively mitigates histamine-and substance P-induced itching in mice, while a higher dose of 100 mg/kg given twice daily for three weeks successfully attenuates oxazolone-induced atopic dermatitis in mice, demonstrating a 51.2% inhibition rate. This is observed in studies involving female ICR and Balb/c mice specifically aged 8 weeks and 6 weeks respectively, weighing 20±3 g. Additionally, pharmacokinetic analysis in both ICR mice and SD rats, with doses respective to their species (50 mg/kg for mice, 10 mg/kg for rats), reveals the compound's absorption and elimination profiles, marked by its half-life, maximum concentration (Cmax), and area under the curve (AUCinf), thus indicating the compound's effective duration and exposure in the body. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Undecane | Betahistine mesylate | Histamine dihydrochloride | Meclizine dihydrochloride | Lidocaine | Famotidine | Sodium butanoate | Nizatidine | Alginic acid | Mianserin hydrochloride | Trazodone hydrochloride | Doxepin hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
Recommended supplier
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
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