JC-171 NEW
| Price | $297 |
| Package | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-22 |
Product Details
| Product Name: JC-171 | CAS No.: 2112809-98-8 |
| Supply Ability: 10g | Release date: 2026/04/22 |
Product Introduction
Bioactivity
| Name | JC-171 |
| Description | JC-171, a selective inhibitor of the NLRP3 inflammasome, effectively inhibits LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages with an IC50 of 8.45 μM[1]. |
| In vitro | JC-171 (0-100 μM) inhibits NLRP3 inflammasome activation and IL-1β production in primary macrophages in a dose-dependent manner, with cell viability assessed using J774A.1 murine macrophage cells[1]. |
| In vivo | JC-171 treatment delays progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE) in mice[1]. Animal Model: Mice immunized subcutaneously with 200 μg Myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide emulsified in Complete Freund's Adjuvant (CFA) on day 0, followed by injection of 200 ng of pertussis toxin. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (8.58 mM), Sonication is recommended. DMSO : 250 mg/mL (649.64 mM), Sonication is recommended. |
| Keywords | JC-171 | JC171 | JC 171 |
| Inhibitors Related | Stavudine | Ascorbyl palmitate | Citraconic acid | Trimethylamine N-oxide | Teneligliptin hydrobromide | NLRP3-IN-2 | Aluminum Hydroxide | N4-Acetylcytidine | (S)-(+)-Carvone | MCC950 | Articaine hydrochloride | Isoandrographolide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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