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Postion:Product Catalog >JCN037
JCN037
  • JCN037

JCN037 NEW

Price $48 $75 $132
Package 5mg 10mg 25mg
Supply Ability: 10g
Update Time: 2026-04-22

Product Details

Product Name: JCN037 CAS No.: 2305154-31-6
Purity: 99.50% Supply Ability: 10g
Release date: 2026/04/22

Product Introduction

Bioactivity

NameJCN037
DescriptionJCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).
In vivoRelative to the conventional EGFR TKIs erlotinib and lapatinib, JCN037 displayed potent activity against EGFR amplified/mutant patient-derived cell cultures, significant BBB penetration (2:1 brain-to-plasma ratio), and superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 10 mg/mL (26.58 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 1 mg/mL (2.66 mM), Sonication is recommended.
KeywordsJGK-037 | JGK037 | JGK 037 | JCN-037 | JCN037 | JCN 037 | Inhibitor | inhibit | HER1 | ErbB-1 | Epidermal growth factor receptor | EGFR
Inhibitors Related(S)-Afatinib | Osimertinib | Lidocaine Hydrochloride hydrate | Lapatinib | Erlotinib hydrochloride | Erlotinib | Neratinib | Afatinib | Chalcone | Brigatinib | Genistein | Gefitinib
Related Compound LibrariesAnti-Lung Cancer Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Ovarian Cancer Compound Library | Anti-Breast Cancer Compound Library | Hematonosis Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Fluorochemical Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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