JDTic Dihydrochloride NEW
| Price | $238 |
| Package | 2mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-01 |
Product Details
| Product Name: JDTic Dihydrochloride | CAS No.: 785835-79-2 |
| Supply Ability: 10g | Release date: 2026/06/01 |
Product Introduction
Bioactivity
| Name | JDTic Dihydrochloride |
| Description | JDTic Dihydrochloride is a high-affinity and selective κ-opioid receptor (KOR) antagonist that blocks dynorphin-KOR signalling, exhibiting antidepressant, anxiolytic, and anti-relapse effects against cocaine and nicotine. |
| In vivo | Methods: In a hangover-induced anxiety rat model, JDTic Dihydrochloride was administered via intraperitoneal injection at 3 mg/kg to assess anxiety-like behavior and at 10 mg/kg to evaluate alcohol-related behaviors, with a 2-hour pretreatment period. Results: JDTic Dihydrochloride (3 mg/kg, ip) significantly reversed anxiety-like behavior in hangover rats; the 10 mg/kg dose reduced alcohol self-administration, suppressed cue-induced reinstatement of alcohol seeking, and specifically blocked the effects of KOR agonists after 2 hours of pretreatment. [2] |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (148.55 mM), Sonication is recommended. H2O : 40 mg/mL (74.27 mM), Sonication is recommended. |
| Keywords | JDTic dihydrochloride | JDTic |
| Inhibitors Related | Docusate sodium | Bevenopran | Mirtazapine | Matrine | (-)-Menthol | Cuminaldehyde | Progesterone | Naltrexone hydrochloride | Cebranopadol | BTRX-335140 | Bisacodyl | Mianserin hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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