K 00546 NEW
| Price | $265 | $920 | $1180 |
| Package | 5mg | 25mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-21 |
Product Details
| Product Name: K 00546 | CAS No.: 443798-47-8 |
| Purity: 99.12% | Supply Ability: 10g |
| Release date: 2026/04/21 |
Product Introduction
Bioactivity
| Name | K 00546 |
| Description | K 00546 is a potent inhibitor of cellular cyclin kinases (CDK1 and CDK2) and CDC2-like kinases (CLK1 and CLK3) used in the study of cancer and immune-related diseases. |
| In vitro | K 00546 binds to the SLK ATP binding site and forms three hydrogen bonds with the kinase hinge residues E109 and C111. In addition, the aminosulfonyl portion of K 00546 interacts with the backbone of L40. [1] K 00546 also inhibits a number of kinases, including PKA, casein kinase-1, MAP kinase (ERK-2), calmodulin kinase, VEGF-R2, GSK-3, and PDGF-Rβ, with IC50 values of 5.2 μM, 2.8 μM, 1.0 μM, 8.9 μM, 0.032 μM, 0.14 μM, and 1.6 μM, respectively. K 00546 is a potent CDK1 and CDK2 inhibitor with IC50 values of 0.6 nM for CDK1/cyclin B and 0.5 nM for CDK2/cyclin A. [2] K 00546 has also been shown to be a potent CDC2-like kinase 1 (CLK1) and CLK3 inhibitor with IC50 values of 8.9 nM and 29.2 nM, respectively. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (188.04 mM), Sonication is recommended. |
| Keywords | K-00546 | K 00546 | GSK-3 | GSK3 | CLK3 | CLK1 | CDK2 | CDK1 |
| Inhibitors Related | Ribociclib | 2-Chloropyrazine | Kojic acid | Sorafenib | Abemaciclib | 4-Chloro-2'-bromoacetophenone | Ethyl linoleate | Nintedanib esylate | Chloramphenicol | Palbociclib | Lenvatinib | Pazopanib |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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