K6PC-5 NEW
| Price | $80 | $128 | $289 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-22 |
Product Details
| Product Name: K6PC-5 | CAS No.: 756875-51-1 |
| Purity: 99.90% | Supply Ability: 10g |
| Release date: 2026/04/22 |
Product Introduction
Bioactivity
| Name | K6PC-5 |
| Description | K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and virus infection, K6PC-5 presents a promising compound for research purposes. |
| In vitro | K6PC-5 (1-10 μM; 24 h) increases involucrin and loricrin levels in a dose-dependent manner in normal human epidermal keratinocytes (NHEKs), promotes differentiation and proliferation of keratinocytes via intracellular Ca2+ signaling, and stimulates the phosphorylation of p42/44 extracellular signal-regulated kinase and c-Jun N-terminal kinase[1]. K6PC-5 (1-10 μM; 24 h) also promotes fibroblast proliferation and collagen synthesis in human fibroblasts, inducing intracellular Ca2+ concentration ([Ca2+]i) oscillations[2]. Additionally, K6PC-5 (10, 25, and 50 μM; 48 h) significantly attenuates EBOV infection in EBOV-infected EA.hy926 cells, reduces virus titers in cell supernatants, and decreases VP40 levels in a concentration-dependent manner[3]. |
| In vivo | In intrinsically aged hairless mice (56 weeks old), topical application of 1% K6PC-5 for 2 weeks significantly increased the number of dermal fibroblasts and collagen production, resulting in a notable increase in dermal thickness[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 49 mg/mL (142.65 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (9.61 mM), Sonication is recommended. |
| Keywords | SphK1 | S1PReceptor | S1P Receptor | K6PC-5 |
| Inhibitors Related | Rifampicin | Phenytoin sodium | Levofloxacin hydrochloride | Ribavirin | Anthraquinone | L-Lysine | L-Lysine hydrochloride | Ofloxacin | Vidarabine | Thymidine | N4-Acetylcytidine | Danthron |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Viral Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Infection Compound Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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