Product Details
| Product Name:
KL201 |
CAS No.:
302939-48-6 |
| Purity:
98.06% |
Supply Ability:
10g |
| Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | KL201 |
| Description | KL201, a circadian clock modulator, is an isoform-selective cryptochrome 1 (CRY1) stabilizer that lengthens the period of circadian rhythms in cells and tissues [1]. |
| In vitro | KL201 induces a dose-dependent extension of the circadian cycle in both Bmal1-dLuc and Per2-dLuc reporter cells, with a more pronounced reduction in the luminosity of the Per2-dLuc reporter compared to Bmal1-dLuc, without compromising cell viability[1]. It interacts with CRY1, coinciding with the FBXL3 segment of the ubiquitin ligase complex, and its circadian-modulating effects are diminished by the silencing of FBXL3[1]. Moreover, KL201 extends the circadian rhythm and diminishes the brightness of the Per2::Luc reporter in mouse lung primary explants[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 3.3 mg/mL (8.5 mM), Sonication is recommended.
DMSO : 250 mg/mL (643.87 mM), Sonication is recommended.
|
| Keywords | Per2-dLuc | KL-201 | KL201 | KL 201 | Inhibitor | inhibit | FBXL3 | cryptochrome | CRY1 | clock | circadian |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
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