Product Details
| Product Name:
KN-93 hydrochloride |
CAS No.:
1956426-56-4 |
| Purity:
99.99% |
Supply Ability:
10g |
| Release date:
2026/04/22 |
Product Introduction
Bioactivity
| Name | KN-93 hydrochloride |
| Description | KN-93 hydrochloride is a cell-permeable, reversible, and competitive inhibitor of calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM. KN-93 hydrochloride induces G1 cell cycle arrest in 95% of treated cells after two days, with the arrest being reversible; one day after KN-93 withdrawal, a peak of cells progresses into S and G2-M phases, providing a robust tool for cell cycle regulation studies and mechanistic investigation of CaMKII-dependent signaling. |
| In vitro | In primary cultured rat retinal Müller cells, KN-93 hydrochloride (10 μmol/L, 24 hours) significantly inhibited the activation of the CaMKII/NF-κB signaling pathway induced by high Vitis vinifera sugar conditions, thereby reducing the mRNA and protein expression levels of inflammatory factors such as VEGF, iNOS, and ICAM-1 [2]. |
| In vivo | KN-93 hydrochloride (1 mg/kg, intraperitoneal injection, for 12 consecutive weeks) significantly inhibited the constitutive activation of the CaMKII/NF-κB signaling pathway in the retina of STZ-induced diabetes mellitus rat models. It effectively reduced the expression levels of vascular endothelial growth factor (VEGF), inducible nitric oxide synthase (iNOS), and intercellular adhesion molecule-1 (ICAM-1), thereby markedly alleviating diabetes mellitus-induced retinal vascular leakage [2]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | KN-93 Hydrochloride | KN 93 Hydrochloride |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | Cysteamine hydrochloride | Guanidine hydrochloride | Hydroxychloroquine | Enzalutamide | Paeonol | Naringin | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Kinase Inhibitor Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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