KRN2 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-21 |
Product Details
| Product Name: KRN2 | CAS No.: 248260-75-5 |
| Supply Ability: 10g | Release date: 2026/04/21 |
Product Introduction
Bioactivity
| Name | KRN2 |
| Description | KRN2 has potential to treat NFAT5-mediated Chronic Arthritis. KRN2 is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 100 nM. |
| In vitro | KRN2 selectively and dose-dependently inhibits the binding of NF-κB p65 to the Nfat5 promoter 1 and impedes its interaction with the DNA binding sequence located in the upstream site (base pairs -3000 to +1) of Nfat5 exon 1. Moreover, KRN2 effectively suppresses the expression of pro-inflammatory genes such as Nos2 and Il6, while sparing the activation of high-salt-induced NFAT5 and related target gene expressions. |
| In vivo | KRN2 (3 mg/kg, i.p., daily) effectively suppresses CIA and AIA in mice by reducing pro-inflammatory cytokines, autoantibodies, and macrophage infiltration. Additionally, KRN2 (3 mg/kg, i.p., daily for 2 weeks) significantly suppresses AIA, where innate immune cells are predominantly involved. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | NFAT5 | KRN-2 | KRN2 | KRN 2 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $31.00 |
VIP6Y
|
TargetMol Chemicals Inc.
|
2026-04-20 | |
| $1980.00 |
VIP2Y
|
TargetMol Chemicals Inc.
|
2025-10-27 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
INQUIRY