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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Stem Cells & Wnt>Wnt / beta-catenin inhibitors>KY02111
KY02111
  • KY02111

KY02111 NEW

Price $35 $77 $143
Package 10mg 25mg 50mg
Supply Ability: 10g
Update Time: 2026-04-22

Product Details

Product Name: KY02111 CAS No.: 1118807-13-8
Purity: 98.68% Supply Ability: 10g
Release date: 2026/04/22

Product Introduction

Bioactivity

NameKY02111
DescriptionKY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
In vivoWhen applied to human embryonic stem cell lines (hESC; KhES-1 and KhES-3), human-induced pluripotent stem cell lines (hiPSC; 253G1, IMR90-1, IMR90-4, and RCHIPC0003), and a mouse embryonic stem cell line (R1), KY02111 (10 μM) significantly increases the proportion of cardiomyocytes by 70%-94%. In IMR90-1 hiPSCs, KY02111 (10 μM) downregulates the expression of 72.7% of target genes in the WNT signaling pathway. Furthermore, in TOPflash assays, a dose-dependent decrease in luciferase reporter activity was observed when KY02111 (10 μM) was applied to HEK293 and IMR90-1 hiPSC cells, indicating a suppression of WNT/β-catenin signaling. Remarkably, doses of KY02111 ranging from 10 μM to 25 μM enhanced cardiac differentiation in transgenic monkey ESCs approximately 80-fold compared to the control group, without exhibiting cytotoxicity at high concentrations. In SW480 cells, KY02111 (10 μM) also significantly reduced luciferase activity in TOPflash assays, highlighting its ineffectiveness against XAV939 and IWP-2. However, KY02111 notably diminished the luciferase activity induced by the GSK3β inhibitor BIO in SW480 cells, outperforming the effects of XAV939 and IWP-2.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 18.8 mg/mL (49.89 mM), Sonication is recommended.
Keywordsβcatenin | Wnt/β-catenin | Wnt/betacatenin | Wnt/b-catenin | Wnt | stem | regeneration | pluripotent | of human | KY-02111 | KY02111 | KY 02111 | Inhibitor | inhibit | differentiation | cells | cardiomyocyte | cardiac | beta-catenin | betacatenin | bcatenin
Inhibitors RelatedChlorquinaldol | Urea | Wnt pathway activator 1 | Neohesperidin | XAV-939 | Ethyl linoleate | Monensin sodium salt | Nimbolide | Isoquercetin | (±)-Nornicotine | Methyl Vanillate | Bisdemethoxycurcumin
Related Compound LibrariesOsteogenesis Compound Library | Anti-Colorectal Cancer Compound Library | Neural Regeneration Compound Library | Reprogramming Compound Library | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Neuroprotective Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Anti-Liver Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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