L-2-Hydroxyglutaric acid NEW
| Price | $113 | $283 | $450 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: L-2-Hydroxyglutaric acid | CAS No.: 13095-48-2 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | L-2-Hydroxyglutaric acid |
| Description | L-2-Hydroxyglutaric acid (L-2-HG) is a compartmentalized metabolite and a substrate for L-2-hydroxyglutarate dehydrogenase (L2HGDH). It inhibits histone demethylases and increases the expression of ATF4 and its target genes by activating the mTOR pathway. L-2-Hydroxyglutaric acid mediates the mTOR-ATF4 signaling pathway and can be used in biosensor research. |
| In vitro | L-2-Hydroxyglutaric acid exhibits potent inhibition of 2-oxoglutarate (2-OG)-dependent dioxygenases (2OGDs), including Ten Eleven Translocation (TET) enzymes. [1] L-2-Hydroxyglutaric acid was able to effectively inhibit mitochondrial creatine kinase (Mi-CK) activity with a Km value of 2.52 mM and a Ki value of 11.13 mM. [2] |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | L-2-Hydroxyglutaric acid | L2Hydroxyglutaric acid | L 2 Hydroxyglutaric acid | Human Endogenous Metabolite | 2-Hydroxyglutaric acid |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium | DL-Lysine |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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