L-AP4 monohydrate NEW
| Price | Get Latest Price | ||
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-15 |
Product Details
| Product Name: L-AP4 monohydrate | CAS No.: 2247534-79-6 |
| Supply Ability: 10g | Release date: 2026/07/15 |
Product Introduction
Bioactivity
| Name | L-AP4 monohydrate |
| Description | L-AP4 (L-APB) monohydrate is a potent and specific agonist for group III mGluRs, with EC50s of 0.13, 0.29, 1.0, and 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively [1][2]. |
| In vivo | Intrathecal injection of L-AP4 (5-30 μg) over 4-5 days notably enhances the paw withdrawal threshold in response to von Frey filament application in eight nerve-ligated rats, demonstrating a dose-dependent effect. This treatment does not lead to any observable motor dysfunction. Furthermore, a specific dose of 30 μg L-AP4 does not significantly change paw withdrawal latency in normal rats. Additionally, the topical application of 5 to 50 μM L-AP4 directly to the spinal cord markedly reduces the neuronal response to sensory stimuli such as touch, pressure, pinch, and von Frey filaments in a concentration-dependent manner. The experiments were conducted using rat models. |
| Storage | Keep away from direct sunlight,Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | L-AP-4 monohydrate | L-AP4 Monohydrate | LAP4 monohydrate | L-AP4 | L AP4 monohydrate |
| Inhibitors Related | IDRA-21 | Urethane | Decanoic Acid | Kynurenic acid | DCB | L-Cysteic acid monohydrate | Evans blue | L-Glutamine | Direct Blue 1 | L-Glutamic acid monosodium salt | Memantine hydrochloride | O-Phospho-L-serine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
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TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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