L-Panthenol

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E-mail: anna@molcoo.com.

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• Product Information

• Product Number: P034008

• English Name: L-Panthenol

• English Alias: (S)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide

• CAS Number: 74561-18-5

• Molecular Formula: C?H??NO?

• Molecular Weight: 205.25

• Advantages

• As a standard or raw material of L-Panthenol, this compound has the following advantages:
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• Well-defined structure with specific bioactivity: Contains a chiral carbon (S-configuration), multiple hydroxyl groups, and an amide moiety. Compared to D-panthenol, the L-isomer is more readily metabolized to pantothenic acid (vitamin B5) in humans, with higher bioavailability. Its hydrogen-bonding network from hydroxyls and amide ensures excellent water solubility (soluble in water and ethanol), suitable for various formulations;

• High stability and compatibility: Stable under neutral to weakly acidic conditions, resistant to oxidation or hydrolysis, and compatible with most cosmetic/pharmaceutical excipients (e.g., glycerin, propylene glycol) without significant incompatibilities;

• Safety and multifunctionality: As a vitamin B5 derivative, it is non-irritating with dual moisturizing and repairing effects. Certified as safe by FDA and EU, it is suitable for sensitive skin and infant products.

• Applications

• Cosmetics and personal care: Used in skincare and shampoos to enhance skin barrier function via hydroxyl-mediated hydration, promote stratum corneum repair, and alleviate dryness or redness;

• Pharmaceuticals: As an excipient in topical formulations (ointments, gels) to accelerate wound healing (e.g., burns, ulcers), and in oral supplements to prevent pantothenic acid deficiency;

• Feed additives: Added to livestock feed to improve skin health, immunity, and coat luster.

• Background Description

• Panthenol, an alcohol derivative of pantothenic acid (vitamin B5), is widely used for its enhanced skin/mucosa permeability. It exists as L and D isomers, with L-Panthenol being the naturally active form. It converts to pantothenic acid in vivo, participating in coenzyme A synthesis to regulate energy metabolism and cell repair. Its polyhydroxyl structure confers strong moisturizing properties, making it a key ingredient in cosmetics and pharmaceuticals.

• Research Status

• Current research focuses on:
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• Formulation innovation: Developing microencapsulated L-panthenol to extend skin retention, enhancing long-term moisturization (e.g., hyaluronic acid microspheres for sustained-release masks);

• Synergistic effect studies: Combinations with ceramides or asiaticoside to boost repair via skin lipid synthesis regulation, shown effective in atopic dermatitis management;

• Synthetic optimization: Biotransformation methods (enzymatic asymmetric reduction) to achieve >99% chiral purity, reducing isomer separation costs;

• Clinical expansion: Exploring applications in dry eye treatment, with 0.5% L-panthenol eye drops shown to improve ocular surface damage via tear secretion promotion

This product is intended for laboratory use only!

WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com