L-Sepiapterin NEW
| Price | $4230 | $5500 |
| Package | 25mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-03 |
Product Details
| Product Name: L-Sepiapterin | CAS No.: 17094-01-8 |
| Purity: 99.97% | Supply Ability: 10g |
| Release date: 2026/06/03 |
Product Introduction
Bioactivity
| Name | L-Sepiapterin |
| Description | L-Sepiapterin is an activator of phenylalanine hydroxylase and also a synthetic precursor of tetrahydrobiopterin, a cofactor of endothelial nitric oxide synthase. L-Sepiapterin can improve endothelial dysfunction in mesenteric arterioles of db/db mice and induce angiogenesis; meanwhile, L-Sepiapterin can also inhibit the proliferation and migration of ovarian cancer cells by downregulating p70S6K-dependent VEGFR-2 expression. Based on the above biological activities, L-Sepiapterin can be applied to mechanistic studies related to hyperphenylalaninemia. |
| In vitro | Methods: Cells were treated with L-Sepiapterin (0.1–10?μM) for 24?hours. Results: L-Sepiapterin induced cell proliferation in a dose?dependent manner. Methods: Cells were first induced with VEGF?A (50?ng/mL), then treated with L-Sepiapterin (1–50?μM) for 20?minutes. Results: L-Sepiapterin significantly inhibited VEGF?A?induced p70S6K phosphorylation. Methods: Relevant intervention experiments were performed using cell proliferation assays. Results: L-Sepiapterin inhibited VEGF?A?induced protein phosphorylation, cell proliferation and migration through an NO?independent mechanism[1]. |
| In vivo | Methods: db/db mice were intragastrically administered L-Sepiapterin (10 mg/kg; via powdered food) once daily for 8 consecutive weeks. Results: L-Sepiapterin significantly improved the relaxation response of superior mesenteric arteries (SMA) to acetylcholine (Ach) in db/db mice[2]. |
| Storage | Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | L-Sepiapterin | LSepiapterin | L Sepiapterin |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Guanidine thiocyanate | glycine | Malic acid | Glycerol | Thymidine | Gluconate Calcium | DL-Lysine |
| Related Compound Libraries | Rare Natural Product Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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