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Postion:Product Catalog >LEI-401
LEI-401
  • LEI-401

LEI-401 NEW

Price $52
Package 1mg
Supply Ability: 10g
Update Time: 2026-05-25

Product Details

Product Name: LEI-401 CAS No.: 2393840-15-6
Purity: 99.11% Supply Ability: 10g
Release date: 2026/05/25

Product Introduction

Bioactivity

NameLEI-401
DescriptionLEI-401 is a selective and potent NAPE-PLD inhibitor that crosses the blood-brain barrier (IC50: 27 nM).LEI-401 reduces the level of n-acylethanolamines (NAEs) in the brain of free-ranging mice and modulates their emotional behaviour.
In vitroIn HEK293T cells transfected with hNAPE-PLD, LEI-401 (0.04 - 20 μM; 30 minutes) dose-dependently reduces the labeling of NAPE-PLD, with an IC50 of 0.86 μM. LEI-401 decreases the levels of NAE in Neuro-2a cells but does not reduce them in NAPE-PLD KO cells[1].
In vivoThe in vivo pharmacokinetic profile of LEI-401 was evaluated in the plasma of C57BL/6J mice following intraperitoneal (i.p., 30 mg/kg), oral (p.o., 10 mg/kg), or intravenous (i.v., 1 mg/kg) administration. The results demonstrate that LEI-401 is an active NAPE-PLD inhibitor in vivo, indicating its suitability for studying the physiological role of NAPE-PLD[1].
StorageStore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 80 mg/mL (189.78 mM), Sonication is recommended.
10% DMSO+90% Corn Oil : 3.3 mg/mL (7.83 mM), Sonication is recommended.
KeywordsPLD | LEI-401 | LEI401
Inhibitors RelatedNeomycin sulfate | Levamisole hydrochloride | 1-Naphthaleneacetic acid potassium salt | Difluprednate | trans-Benzylideneacetone | Benzylideneacetone | Omeprazole | Indomethacin | Darapladib | 1-Naphthaleneacetic acid | Lansoprazole | Magnesium sulfate

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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