Product Details
| Product Name:
Lemildipine |
CAS No.:
94739-29-4 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | Lemildipine |
| Description | Lemildipine is a new blocker of dihydropyridine calcium entry. |
| In vivo | Lemildipine significantly reduces blood pressure in spontaneously hypertensive rats (SHR), being 1.4 times more potent than Nifedipine, with ED30 values of 10.2 mg/kg and 14.3 mg/kg, respectively[2]. Intraperitoneal administration of Lemildipine (0.1-3 mg/kg) to gerbils after occlusion results in a significant increase in neuronal cell density (NCD) in the CA1 subfield four days post-ischemia, from 43±10.8 cells/mm in the control group to 143±24.2 cells/mm in the Lemildipine (3 mg/kg) group (P<0.01). In normal Wistar rats (NWR), oral Lemildipine (3-30 mg/kg) produces mild, dose-dependent reductions in systolic blood pressure. Lemildipine (3 mg/kg) also significantly inhibits delayed neuronal death (DND) at 1, 2, and 4 weeks post-ischemia, with average NCD values of 80±9.4 (P<0.01), 92±13.7 (P<0.05), and 57±5.0 (P<0.01) cells/mm compared to control values of 43±7.7, 52±9.3, and 43±12.4 cells/mm, respectively. The protective effects of Lemildipine in the hippocampal CA1 subfield persist for up to 4 weeks after transient forebrain ischemia[1]. The maximum blood pressure reduction occurs 1-3 hours post-administration. Hypotensive potency, measured using dose-response curves and ED30, reaffirms Lemildipine's greater efficacy compared to Nifedipine. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | NPK1886 | NPK 1886 | NB818 | NB 818 | Lemildipine | Calcium entry |
| Inhibitors Related | Quadrol | Tricaine methanesulfonate | Nisoldipine | 2,4,6-Tri-tert-butylphenol | Chlorocresol | L-Ascorbic acid | L-Phenylalanine | L-Ascorbic acid sodium salt | 2-Nitrobenzoic acid | Magnesium Chloride Hexahydrate | Magnesium sulfate | Cinchonine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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