Clindamycin hydrochloride is regarded as one of the 20 most important antibiotics because of its strong anti-infection ability and wide therapeutic range. From the perspective of structure, Lincomycin hydrochloride is formed by the condensation and modification of Lincosamide (LSM) and Chemicalbook Propylproline (PPL). In recent years, the biosynthesis mechanism of lincomycin has made substantial achievements, and the biosynthesis pathway is becoming clear.