Lith-O-Asp NEW
| Price | $523 | $1520 | $1980 |
| Package | 5mg | 25mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-01-05 |
Product Details
| Product Name: Lith-O-Asp | CAS No.: 881179-02-8 |
| Supply Ability: 10g | Release date: 2026/01/05 |
Product Introduction
Bioactivity
| Name | Lith-O-Asp |
| Description | Lith-O-Asp is a sialytransferase (ST) inhibitor with IC50 values ranging from 12 to 37 μM. |
| In vitro | The results indicate that Lith-O-Asp reduces the activity of both a-2,3- and a-2,6-sialyltransferases, consequently inhibiting the transfer of sialic acids to target glycoproteins[1]. Despite showing no significant growth inhibition effect on various cancer cell lines at doses of 10, 30, and 60 μM, in vitro assays reveal Lith-O-Asp's capability to suppress the activities of ST3Gal I, ST3Gal III, and ST6GalI, with IC50 values ranging from 12 to 37 μM. Furthermore, flow cytometry analysis demonstrates a marked decrease in the expression of cell surface a-2,3- and a-2,6-sialylated antigens. |
| In vivo | In lung tissues of mice treated with DMSO and observed using the IVIS in vivo imaging system, a significant presence of secondary metastatic cancer cells was noted 26 days post-fat pad inoculation. Conversely, mice treated with Lith-O-Asp exhibited a reduction in lung metastases, with only 3 of 8 mice showing any metastasis compared to all DMSO-treated mice. The average number of tumor nodules per mouse in the DMSO group was 11±9, while in the Lith-O-Asp group, it was significantly lower at 2±4 nodules. Additionally, 4T1-Luc illumination signals, indicating tumor presence, were markedly stronger in the DMSO control group than in the Lith-O-Asp-treated group on days 7 and 9[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 106 mg/mL (215.6 mM), Sonication is recommended. |
| Keywords | ST | Lith-O-Asp | LithOAsp | Lith O Asp |
| Inhibitors Related | Alendronate sodium trihydrate | Serotonin hydrochloride | Rosmarinic acid | D(+)-Raffinose pentahydrate | Risedronic Acid | 3-Methoxybenzamide | Entacapone | CBHcy | Eliglustat hemitartrate | (-)-Gallocatechin gallate | Flopropione | Tolcapone |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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