Lupeol acetate NEW
| Price | $263 |
| Package | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Lupeol acetate | CAS No.: 1617-68-1 |
| Purity: 99.84% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Lupeol acetate |
| Description | Lupeol acetate is a derivative of Lupeol with anti-cancer, anti-inflammatory, anti-diabetic, anti-snake venom, anti-fertility effects and oral activity. It is able to inhibit rheumatoid arthritis by down-regulating inflammatory cytokines (TNF-α, IL-1β, MCP-1, COX-2, VEGF, granzyme B) and is cytotoxic to Hep-3B and A549 cells. |
| In vitro | Methods: Lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and bone marrow-derived macrophages (BMDM) were treated with Lupeol acetate (0-80μM) and TNF-α, IL-1β, COX-2, and MCP-1 were measured using Western blotting. In addition, bone formation was examined using reverse transcription-PCR (RT-PCR) and tartrate-resistant acid phosphatase (TRAP) staining. Results: Lupeol acetate inhibited the activation, migration, and formation of macrophage osteoclastogenesis in a dose-dependent manner. [3] |
| In vivo | Methods: DBA/1J mice with collagen-induced arthritis (CIA) were randomly divided into three groups: vehicle, Lupeol acetate-treated (50mg/kg), and curcumin-treated (100mg/kg). The therapeutic effects were determined by clinical scores, expression levels of serum cytokines including TNF-α and IL-1β, (18)F-fluorodeoxyglucose ((18)F-FDG) microPET/CT, and histopathology. Results: In RA-bearing mice, the expression of inflammatory-related cytokines was suppressed, and LA improved clinical symptoms and bone erosion. Lupeol acetate also significantly reduced the accumulation of (18)F-FDG in the joints of RA-bearing mice. Lupeol acetate significantly improved the symptoms of RA by downregulating the expression of inflammatory cytokines and osteoclastogenesis. [3] |
| Storage | Keep away from direct sunlight,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 1 mg/mL (2.13 mM), Sonication is recommended. |
| Keywords | TNF-α | NOS | NO Synthase | Lupeol Acetate |
| Inhibitors Related | Neomycin sulfate | Calcium Propionate | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Hydroxypropyl Cellulose | Fenpyroximate | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Trometamol | Gluconate Calcium | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Apoptosis Compound Library | Anti-Parasitic Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Selected Plant-Sourced Compound Library | Anti-Fungal Compound Library | Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Bioactive Lipid Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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