Product Details
| Product Name:
Mahanimbine |
CAS No.:
21104-28-9 |
| Supply Ability:
10g |
Release date:
2026/06/15 |
Product Introduction
Bioactivity
| Name | Mahanimbine |
| Description | Mahanimbine is found in the roots, leaves and stems of Murraya koenigii and is an orally active alkaloid extracted from Murraya koenigii. Bifidobacterium bifidum leaves on histopathological changes in pancreatic beta cells of streptozotocin-induced diabetic rats. |
| In vitro | Mahanimbine induces cell cycle arrest at the G0/G1 phase and apoptosis in Capan-2 and SW1190 cancer cells when used at a concentration of 7 μM, as well as inhibits proliferation in Capan-2, SW1190, BxPC-3, CFPAC-1, and HPAF-II cancer cells (IC50s = 3.5, 3.5, 16, 64, and 32 μM, respectively).[2]
It is active against S. aureus and S. pyogenes (MIC100 = 50 μg/ml for both), as well as A. aegypti fourth instar larvae when used at a concentration of 100 μg/ml.[3] |
| In vivo | Mahanimbine treatment improves glucose clearance and upregulates the expression of insulin-responsive genes in the liver and adipose tissue. Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress. Mahanimbine (2-4 mg/kg ; p.o. ; daily for 12 weeks) prevents HFD-induced weight gain in mice (male and female).[1] |
| Storage | Store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Mahanimbine | AChE |
| Inhibitors Related | Sodium propionate | Kojic acid | Uridine | Fumaric acid | 1,4-Naphthoquinone | Glucosamine | Ethyl linoleate | D-Psicose | N,N-Dimethylacetamide | Dimethyl sulfoxide | Coumaran | Magnesium sulfate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
|
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States