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Postion:Product Catalog >API>Inhibitors>Mavacamten
Mavacamten
  • Mavacamten
  • Mavacamten
  • Mavacamten
  • Mavacamten
  • Mavacamten

Mavacamten

Price $23
Package 1kg
Min. Order: 1kg
Supply Ability: 500tons
Update Time: 2024-01-08

Product Details

Product Name: Mavacamten CAS No.: 1642288-47-8
Min. Order: 1kg Purity: 99.96%
Supply Ability: 500tons Release date: 2024/01/08

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Chemical Name : Mavacamten(MYK-461) 


CAS Number : 1642288-47-8


                                              

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biological activity

Maveacamten (MYK-461, SAR 439152) is a small molecule regulator of cardiac myosin, which regulates the excessive contraction of sarcomere in hypertrophic cardiomyopathy.

In vitro study

MYK-461 reduces the activity of steady-state ATPase by inhibiting the phosphate release rate of β -cardiac myosin -S1. MYK-461 regulates several steps in the chemical-mechanical cycle of myosin: in addition to reducing the rate-limiting step (phosphate release) in this cycle, MYK-461 also reduces the number of myosin-S1 heads (myosin-S1 heads can interact with actin filaments when the weak binding state changes to the strong binding state). MYK-461 can also reduce the binding rate of myosin to ADP- actin and the release rate of ADP from myosin-S1.

In vivo study

In the mouse model transplanted with myosin heavy chain containing human heterozygous mutation, early and long-term administration of MYK-461 (MYK-461) can inhibit the development of ventricular hypertrophy, myocardial cell disorder and myocardial fibrosis, and reduce the expression of genes related to hypertrophy and fibrosis.





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Company Profile Introduction

-WUHAN BOYUAN IMPORT & EXPORT CO.,LTD.. is specialized in R&D, manufacturing and marketing APIS, Food Additives,Inorganic Chemicals,Organic Intermediate,Health Care Products,Feed Additives,Chemical Reagents,Daily Chemicals etc.More than 70 percent products are exported to Europe, America, Japan and Southeast Asia. In the past years, WUHAN BOYUAN IMPORT & EXPORT CO.,LTD. has established its professional team and advanced managements, excels in product sourcing and customized products. WUHAN BOYUAN IMPORT & EXPORT CO.,LTD. has built close collaborations with several well-known institutes in China. Development of new fine chemical, custom synthesis has been a significant part of our chemical's production. The essence of our business is commitment to customer service by meeting and/or exceeding our client's expectations of cost, quality, and efficient service. We are confident that our competitive edge will provide the foundation ensure for our customers to be successful in their own market areas. Our company offers variety of products which can meet your multifarious demands. We adhere to the management principles of "quality first, customer first and credit-based" since the establishment of the company and always do our best to satisfy potential needs of our customers. Our company is sincerely willing to cooperate with enterprises from all over the world in order to realize a win-win situation since the trend of economic globalization has developed with anirresistible force

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