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Postion:Product Catalog >API>Antineoplastic agents>Antimetabolites, Antineoplastic>Methotrexate
Methotrexate
  • Methotrexate
  • Methotrexate
  • Methotrexate
  • Methotrexate
  • Methotrexate

Methotrexate NEW

Price Get Latest Price
Package 1kg
Min. Order: 1kg
Supply Ability: 10000kg
Update Time: 2025-04-02

Product Details

Product Name: Methotrexate CAS No.: 59-05-2
EC-No.: 200-413-8 Min. Order: 1kg
Purity: 99% Supply Ability: 10000kg
Release date: 2025/04/02

Manufacturer ProvidRaw Material CAS 59-05-2 Methotrexate Powder Methotrexate 99%


Article illustration

Introduction

Product Name:Methotrexate

Other Name :sodium 4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]am ino]-5-hydroxy-5-oxo-pentanoate

CAS NO:59-05-2

Purity: 99%min
Appearance:Yellow Powder

Molecular formula:C20H22N8O5

Article illustration

Molecular weight :454.45

Melting Point :195°C

Boiling Point :561.26°C (rough estimate)

Density :1.4080 (rough estimate)

Storage:Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate arrests the cell cycle in late G1/S-phase, therefore inhibiting the synthesis of DNA, RNA, thymidylates, and proteins. In the previous cases the inhibition of enzymes involved in purine metabolism, leading to accumulation of adenosine, or the suppression of intercellular adhesion molecule expression by T cells as the main mechanism of action by methotrexate. The compound has been observed to irreversibly inhibit dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). Methotrexate has been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. In adherent splenic cells, IL-1 production was decreased by methorexate.

Function
1.It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and for medical abortions.
2.It is used for include breast cancer, leukemia, lung cancer, lymphoma, and osteosarcoma.Types of autoimmune diseases
3.It is used for include psoriasis, rheumatoid arthritis, and Crohn's disease.
Application
Methotrexate is used as a disease-modifying treatment for some autoimmune diseases, including rheumatoid arthritis, juvenile dermatomyositis, psoriasis, psoriatic arthritis, lupus, sarcoidosis, Crohn's disease (although a recent review has raised the point that it is fairly underused in Crohn's disease), eczema and many forms of vasculitis. Although originally designed as a chemotherapy drug (using high doses), in low doses, methotrexate is a generally safe and well tolerated drug in the treatment of certain autoimmune diseases.


Article illustration


Company Profile Introduction

Shaanxi TNJONE Pharmaceutical Co., Ltd supplies more than 2,000 kinds of products, covering the whole field of health industry, including human APIs, veterinary APIs, food additives, natural nutrition ingredients, feed additives, cosmetic additives, intermediates etc. With global sourcing advantages, the group is fully capable of meeting the one-stop sourcing needs of global customers. Today, Shaanxi TNJONE Pharmaceutical Co., Ltd.'s marketing network has spread over more than 100 countries and regions on five continents, providing professional service for global customers.

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