Product Details
| Product Name:
MF498 |
CAS No.:
915191-42-3 |
| Supply Ability:
10g |
Release date:
2026/04/21 |
Product Introduction
Bioactivity
| Name | MF498 |
| Description | MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed a strong binding affinity for the EP4 receptor (Ki: 0.7 nM). |
| In vitro | MF498 inhibits PGE2-stimulated cAMP accumulation in a dose-dependent manner (IC50: 1.7 and 17 nM in the absence and presence of 10% serum, respectively). MF498 also displays a relatively good selectivity over other prostanoid receptors, does not compromise the mucosal integrity in the gastrointestinal tract. |
| In vivo | MF498 on inflammation in adjuvant-caused arthritis (AIA), a rat model for rheumatoid arthritis (RA), and joint pain in a guinea pig model of iodoacetate-induced osteoarthritis (OA). MF498 relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 2 mg/mL (3.31 mM), Sonication is recommended.
DMSO : 31 mg/mL (51.35 mM), Sonication is recommended.
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| Keywords | MF-498 | MF498 | MF 498 |
| Inhibitors Related | Angoroside C | Ufenamate | Pranoprofen | Tranilast | Rutin | Ozagrel | Ethamsylate | Rebamipide | Evodiamine | Lornoxicam | Nepafenac | p-Hydroxycinnamic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States