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Postion:Product Catalog >MI-538
MI-538
  • MI-538

MI-538 NEW

Price $58 $118 $198
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: MI-538 CAS No.: 1857417-10-7
Purity: 99.80% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameMI-538
DescriptionMI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM).
In vitroTreatment with MI-538 results in strong down regulation of expression of Hoxa9 and Meis1 genes. About 100 nM 27 was sufficient to reduce by ~50% Hoxa9 expression in MLL-AF9 cells, and even more pronounced effect was seen on Meis1 expression.
In vivoTreatment with MI-538 leads to an approximately 80% reduction in MV4;11 tumor volume, with minimal toxicity, evidenced by less than a 10% decrease in body weight.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (17.65 mM), Sonication is recommended.
DMSO : 95 mg/mL (167.67 mM), Sonication is recommended.
KeywordsMI-538 | MI538 | MI 538 | Menin-MLL | menin and MLL interaction | menin | Inhibitor | inhibit | HistoneMethyltransferase | Histone Methyltransferase | EpigeneticReaderDomain | Epigenetic Reader Domain
Inhibitors RelatedMAK-683 hydrochloride | ABBV-744 | 3-methyl-1,2,3,4-tetrahydroquinazolin-2-one | Tazemetostat | Piribedil | 5-Ph-IAA | Curcumin | EPZ015666 | iso-Azalansta | Naphthol AS-E | MRTX-1719 | JQ-1 (carboxylic acid)
Related Compound LibrariesReprogramming Compound Library | Histone Modification Compound Library | Methylation Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Epigenetics Compound Library | Chromatin Modification Compound Library | Inhibitor Library | PPI Inhibitor Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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