MIK665 NEW
| Price | $135 | $289 | $455 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-09 |
Product Details
| Product Name: MIK665 | CAS No.: 1799631-75-6 |
| Purity: 95.47% | Supply Ability: 10g |
| Release date: 2026/06/09 |
Product Introduction
Bioactivity
| Name | MIK665 |
| Description | MIK665 (S-64315) is a small-molecule inhibitor and a myeloid cell leukemia sequence 1 (MCL1) inhibitor (IC50 = 1.81 nM) with high selectivity and cell permeability. Used in experimental research, this compound exhibits antitumor activity in hematologic malignancies such as acute myeloid leukemia. |
| Cell Research | MIK665 suppresses H929 cells (IC50: 250 nM). |
| In vitro | Methods: In AML cells including U937, MV4-11, MOLM-13, and OCI-AML3, 7-AAD/Annexin V staining, Western blot (PARP, caspase-3), and Median Dose-Effect analysis were performed, with cells treated with 1–10 nM MIK665 combined with 2 μM SKI-606 for 24 h. Results: MIK665 and SKI-606 synergistically induced apoptosis, manifested by increased cleavage of PARP and caspase-3, and formation of γH2AX.[1] Methods: In MDS-L, SKM-1, and primary MDS cells, MTS assay and Caspase-Glo 3/7 detection were used, with 50 nM MIK665 alone or combined with GNA treatment for 24–48 h. Results: MIK665 alone mildly inhibited proliferation and increased caspase 3/7 activity; when combined with GNA, it significantly enhanced anti-proliferative and pro-apoptotic effects, and synergistically upregulated Fas expression.[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 250 mg/mL (285.58 mM), Sonication is recommended. H2O : Insoluble, insoluble 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (5.71 mM), Sonication is recommended. |
| Keywords | S64315 | S 64315 | MIK-665 | MIK665 | MIK 665 | Mcl-1 |
| Inhibitors Related | Cyanoacetamide | Ascorbyl palmitate | Pendimethalin | Amantadine | Hydralazine hydrochloride | Semaglutide | Estradiol benzoate | Navitoclax | N-Hydroxyphthalimide | Venetoclax | Benzbromarone | Thymoquinone |
| Related Compound Libraries | Apoptosis Compound Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | PPI Inhibitor Library | Clinical Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $135.00 |
VIP6Y
|
TargetMol Chemicals Inc.
|
2026-06-09 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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