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Postion:Product Catalog >Minalrestat
Minalrestat
  • Minalrestat

Minalrestat NEW

Price $258 $642 $913
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-04-22

Product Details

Product Name: Minalrestat CAS No.: 129688-50-2
Purity: 99.88% Supply Ability: 10g
Release date: 2026/04/22

Product Introduction

Bioactivity

NameMinalrestat
DescriptionMinalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.
In vitroMinalrestat (100 μM) reduces intracellular sorbitol content in primary cultured rat cells without affecting intracellular glucose levels.[3] Minalrestat (100 μM, 48 h) causes the accumulation of PKC-α and -β2 in primary cultured rat mesangial cells.[3]
In vivoThe diabetic group was treated from 3 days after the alloxan injection with Minalrestat (10 mg/kg/day) for 30 days and the Minalrestat treatment (10 mg/kg/day/7 days) of galactosemic rats started concomitantly with the induction of galactosemia. The impaired responses to bradykinin, histamine, and platelet-activating factors of arterioles and venules observed in diabetic and galactosemic rats were completely prevented by Minalrestat. Neither diabetes nor galactosemia affected responses to acetylcholine and sodium nitroprusside. Responses to these agents were not modified by aldose reductase inhibition. The restoring effect of Minalrestat was reversed by inhibition of nitric oxide (NO) synthesis with N(omega)-nitro-L-arginine methyl ester, by blocking K(+) channel with tetraethylammonium but not by cyclooxygenase inhibition with diclofenac.[1]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 45 mg/mL (100.18 mM), Sonication is recommended.
KeywordsWAY-ARI509 | WAYARI509 | WAY-ARI 509 | WAYARI 509 | WAY 121509 | Minalrestat | ARI 509 | Aldose reductase
Inhibitors RelatedFH1 | Furaneol | Epalrestat | Quercitrin hydrate | Dicoumarol | 4-hydroxyphenyl acetate | Lapisteride | Alpha-Estradiol | Finasteride | Isoliquiritigenin | AKR1C1-IN-1 | Kopexil
Related Compound LibrariesGlycometabolism Compound Library | Bioactive Compound Library | Anti-Diabetic Compound Library | Inhibitor Library | Orally Active Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Fluorochemical Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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