Mitiglinide NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Mitiglinide | CAS No.: 145375-43-5 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Mitiglinide |
| Description | Mitiglinide (KAD-1229) is an insulinotropic agent that is an ATP-sensitive K + (K ATP ) channel antagonist. Mitiglinide is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell K ATP channel). Mitiglinide is able to be used for the research of type 2 diabetes [1] [2]. |
| In vitro | In COS-1 cells, Mitiglinide inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC 50 of 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (over 10 μM) [1]. |
| In vivo | Mitiglinide, administered orally at doses ranging from 1 to 3 mg/kg, effectively reduces the postprandial elevation in plasma glucose levels and decreases the glucose area under the curve (AUCglucose) for up to five hours following a meal [2]. This dose-dependent suppression of AUCglucose was observed in an animal model involving pregnant Wistar rats aged 12 weeks, with dosages administered at 0.3 mg/kg, 1 mg/kg, and 3 mg/kg [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Mitiglinide |
| Inhibitors Related | Minoxidil sulfate | Uridine 5'-monophosphate disodium salt | Tannic acid | Hydrochlorothiazide | 1,8-Cineole | Tetraethylammonium bromide | Ursodeoxycholic acid | Chenodeoxycholic acid | Minoxidil | 2,2,2-Trichloroethanol | Chlorzoxazone | Indapamide |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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