MKI-1 NEW
| Price | $61 | $147 | $222 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-14 |
Product Details
| Product Name: MKI-1 | CAS No.: 1190277-80-5 |
| Purity: 99.81% | Supply Ability: 10g |
| Release date: 2026/07/14 |
Product Introduction
Bioactivity
| Name | MKI-1 |
| Description | MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cancer. |
| In vitro | MKI-1 (20 μM, 16 h) reduces c-Myc stability through PP2A activation in MCF7 cells. MKI-1 (5-20 μM) inhibits the activity of MASTL in breast cancer cells. MKI-1 (100 μM, 72 h) inhibits various oncogenic properties of breast cancer cells but showed much weaker effects on the viability of normal breast cells. MKI-1 clearly reduces both total c-Myc and serine 62-phosphorylation of c-Myc, with a decrease in ENSA phosphorylation[1]. |
| In vivo | MKI-1 (50 mg/kg, ip, twice a week) enhances the radiosensitivity of the BT549 xenograft model to 6 Gy irradiation, reducing tumor growth without significant changes in body weight [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 225 mg/mL (744.22 mM), Sonication is recommended. |
| Keywords | MKI-1 | MKI1 | MKI 1 | microtubule-associated serine/threonine kinase-like |
| Related Compound Libraries | Bioactive Compound Library | Anti-Breast Cancer Compound Library | Microtubule-Targeted Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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