Product Details
| Product Name:
ML 145 |
CAS No.:
1164500-72-4 |
| Purity:
97.74% |
Supply Ability:
10g |
| Release date:
2026/07/27 |
Product Introduction
Bioactivity
| Name | ML 145 |
| Description | ML 145 is a selective and potent antagonist of human GPR35, with no significant activity against GPR35 in any of its immediate rodent homologs.ML 145 has potential anti-inflammatory activity for the study of immunoinflammation.ML 145 is a novel non-steroidal anti-inflammatory agent for the study of rheumatoid arthritis. |
| In vitro | ML 145 is a selective and competitive human antagonist of GPR35/CXCR8 with an IC50/EC50 value of 20.1 nM, compared to GPR35, which is over 1000-fold more selective than GPR55, which has an IC50/EC50 value of 21.7 μM. [1]
In addition, ML 145 at 10 μM completely blocked the internalization of human FLAG-GPR35-eYFP in response to various concentrations of Zaprinast, Cromolyn disodium and Pamoate. In rodents, ML 145 was ineffective in mice and showed only a slight non-competitive inhibitory effect in rats. [2] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 40 mg/mL (82.89 mM), Sonication is recommended.
|
| Keywords | ML-145 | ML 145 | GPR35 |
| Inhibitors Related | Tannic acid | Monomethyl fumarate | Kynurenic acid | Pamoic acid disodium | Azathioprine | Soquelitinib | CRTh2 antagonist 2 | Fezagepras sodium | N-Methyltyramine hydrochloride | Benzyl nicotinate | TUG-1375 | Nicotinamide N-oxide |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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United States