Product Details
| Product Name:
MNK8 |
CAS No.:
2055078-49-2 |
| Purity:
99.93% |
Supply Ability:
10g |
| Release date:
2026/07/15 |
Product Introduction
Bioactivity
| Name | MNK8 |
| Description | MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1]. |
| In vitro | MNK8, at a concentration of 50 μM over a period of 0 to 48 hours, resulted in a time-dependent increase in Sub-G1 cells and concurrently led to a reduction in the levels of antiapoptotic proteins, namely Bcl-2, survivin, and cyclin D1 [1]. |
| Storage | Keep away from direct sunlight,
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 55 mg/mL (218.02 mM), Sonication is recommended.
|
| Keywords | Survivin | STAT3 inhibitor | STAT3 | STAT | N-methyluracil derivatives | MNK8? | MNK-8 | MNK8 | MNK 8 | Inhibitor | inhibit | HepG2 | hepatocellular carcinoma | HCC cells | Bcl-2 Family | Apoptosis | Antimigratory agent | Anticancer |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Dextran sulfate sodium salt (MW 5000) | Sildenafil citrate |
| Related Compound Libraries | Reprogramming Compound Library | Bioactive Compound Library | Hematonosis Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Anti-Prostate Cancer Compound Library | Immuno-Oncology Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library | Transcription Factor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States