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Postion:Product Catalog >MP-A08
MP-A08
  • MP-A08

MP-A08 NEW

Price $33 $53 $103
Package 5mg 10mg 25mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: MP-A08 CAS No.: 219832-49-2
Purity: 98.04% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameMP-A08
DescriptionMP-A08 is a highly selective, ATP-competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 [Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively].
In vitroMP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type. MP-A08 blocks pro-proliferative signaling pathways causes mitochondrial-associated apoptosis in an SK-dependent manner. It also reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis [2]
In vivoMP-A08 inhibits the growth of human lung tumour xenografts in mice.
StoragePowder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationH2O : insoluble
DMSO : 55 mg/mL (105.84 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.85 mM), Sonication is recommended.
KeywordsSphK1 | SphK | Sphingosine kinase | S1PReceptor | S1P Receptor | MP-A-08 | MP-A08 | MPA08 | MP A08 | Inhibitor | inhibit
Inhibitors RelatedFingolimod hydrochloride | SLP9101555 | BMS-960 | LX-2931 | Sphingosine-1-phosphate | CYM50374 | ASP-4058 | Ceranib-2 | Siponimod | Ozanimod | W140 HBr | Etrasimod

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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