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Postion:Product Catalog >Chemical Reagents>Organic reagents>Polyamines>MPEG-2000-DSPE
MPEG-2000-DSPE
  • MPEG-2000-DSPE

MPEG-2000-DSPE

Price Get Latest Price
Package 1g 25g
Min. Order: 1g
Supply Ability: 5KG
Update Time: 2026-06-05

Product Details

Product Name: MPEG-2000-DSPE CAS No.: 147867-65-0
Min. Order: 1g Purity: 99%
Supply Ability: 5KG Release date: 2026/06/05

MPEG-2000-DSPE (methoxy poly(ethylene glycol)-2000-distearoylphosphatidylethanolamine) is a PEGylated phospholipid widely used as a functional excipient in drug delivery systems. Its main applications include:


1. Long?circulating liposomes

When incorporated into liposome bilayers (typically 5–20 mol%), the PEG chain creates a steric barrier that reduces opsonization and uptake by the mononuclear phagocyte system (MPS), significantly prolonging circulation half?life.

  • Clinical example: Doxil? (pegylated liposomal doxorubicin) uses MPEG?2000?DSPE to achieve a half?life of ~2.5 days in humans, compared to <0.1 day for conventional liposomes.


2. Polymeric micelles

MPEG?2000?DSPE has a very low critical micelle concentration (CMC), enabling it to self?assemble into stable micelles that solubilize poorly water?soluble drugs.

  • Examples: Used to encapsulate edaravone, paclitaxel, and other hydrophobic agents, improving stability, bioavailability, and targeted delivery in conditions such as cancer and neurodegenerative diseases.


3. Surface modification for active targeting

The terminal methoxy group can be replaced with targeting ligands (e.g., antibodies, peptides) via functionalized PEG?lipid derivatives, allowing active targeting of specific cells or tissues.


Key properties

  • Appearance: White powder

  • Solubility: Soluble in chloroform, methanol, and water (~3–4 g/100 mL)

  • Storage: –20?°C, protected from light and oxidation


Company Profile Introduction

Founded in 2006 and headquartered in Wuhan, Hubei, China, Watson Biotechnology Co., Ltd is a leading manufacturing powerhouse specializing in the production of Active Pharmaceutical Ingredients (APIs) and Intermediates, Food and Feed Additives, Agricultural and Aquaculture chemicals, and Fine Chemicals. As a dedicated factory, our operations are driven by a commitment to excellence and innovation, ensuring that our products meet the highest standards of quality and compliance. With a robust team of over 100 skilled professionals, Watson Biotechnology has established itself as a trusted name in the industry. Our products are meticulously crafted to align with international standards such as USP (United States Pharmacopeia), EP (European Pharmacopoeia), and BP (British Pharmacopoeia), guaranteeing reliability and efficacy. At Watson Biotechnology, we pride ourselves on our cutting-edge facilities and state-of-the-art technology, which enable us to deliver superior products that cater to a diverse range of needs across various sectors. Our dedication to continuous improvement and customer satisfaction drives us to maintain stringent quality control processes and foster an environment of innovation and growth. Join us at Watson Biotechnology Co., Ltd as we continue to pioneer advancements in biotechnology and contribute to a healthier, more sustainable future.

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  • Address: No. 16, 20th Floor, Unit 2, Kaixin Houhu Life Plaza, Tazi Lake, Jiang'an District, Wuhan City, Hubei
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