MRS 1523 NEW
| Price | $198 | $678 |
| Package | 1mg | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2025-12-22 |
Product Details
| Product Name: MRS 1523 | CAS No.: 212329-37-8 |
| Supply Ability: 10g | Release date: 2025/12/22 |
Product Introduction
Bioactivity
| Name | MRS 1523 |
| Description | MRS 1523 can exert an antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons. MRS 1523 is an effective and selective adenosine A3 receptor antagonist Ki: 18.9 nM and 113 nM for human and rat A3 receptors, respectively). In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively. |
| In vitro | NECA-induced migration is blocked in dose-response fashion by MRS 1523 with calculated Ki of 147 nM[4]. When human endothelial progenitor cells (hEPC) are co-incubated with MRS 1523 (1 nM), a partial blockade of the adenosine-5'-N-ethylcarboxamide (NECA)-induced migration is observed. Furthermore, in 3-days hEPC, the treatment with MRS 1523 100 nM inhibits the NECA-induced migration by 70%. MRS 1523 (0.1-1 μM) treatment obviously antagonizes cell numbers to 40.7% and 57.4% of the control values, respectively, 30 min before the addition of cordycepin (60 μM). MRS1523 (1 μM) alone has any effect on tumor cell growth[3]. |
| In vivo | Current-clamp recordings demonstrated that neuronal firing of rat DRG neurons was also significantly reduced by A3AR activation in a MRS 1523-sensitive but PD173212-insensitive manner. The endogenous agonist adenosine reduces N-type Ca currents, and its effect is inhibited by 56% in the presence of A3AR antagonist MRS 1523 [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Rat A3 receptor | MRS-1523 | MRS1523 | MRS 1523 | Human A3 receptor | A2A receptor | A1 receptor |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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