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Postion:Product Catalog >MS-444
MS-444
  • MS-444

MS-444 NEW

Price $799
Package 2mg
Supply Ability: 10g
Update Time: 2026-04-22

Product Details

Product Name: MS-444 CAS No.: 150045-18-4
Purity: 99.45% Supply Ability: 10g
Release date: 2026/04/22

Product Introduction

Bioactivity

NameMS-444
DescriptionMS-444 (BE-34776) is a smooth muscle myosin light chain kinase (MLCK) and HuR inhibitor with antitumor activity for triple-negative breast and colorectal cancer.
In vitroMS-444 is a small molecule RNA-binding protein HuR (ELAVL1) inhibitor. Colorectal cancer (CRC) cells that show HuR overexpression are treated with MS-444 (1-100 μM) for 48 hr (HCT116 IC50=10.98 μM, HCA-7 IC50=12.84 μM, RKO IC50=5.60 μM, HT-29 IC50=14.21 μM, and SW480 IC50=10.98 μM). Contrasting effects are observed using non-transformed small intestinal (RIE-1 IC50=40.70 μM) and colonic epithelial cells (YAMC IC50=28.16 μM). [1]
In vivoMice bearing HCT116 cell xenografts receive intraperitoneal injections of MS-444 (25 mg/kg) or vehicle every 48 hr to test the effects of MS-444 on CRC cell growth in vivo. Anti-tumor effects of MS-444 are observed with an approximately 1.7-fold reduction in tumor size. Mice treated with MS-444 shows a marked 2- to 3-fold reduction in microvessel density (MVD), showing the anti-angiogenic potential of MS-444. [1]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 40 mg/mL (173.75 mM), Sonication is recommended.
Keywordsthreoninkinase | threonin kinase | Serinekinase | Serine kinase | Myosin | MS-444 | MS 444 | MLCK | BE 34776
Inhibitors RelatedMavacamten | Fasudil | Bicyclol | Piceatannol | Chymotrypsin | Fasudil hydrochloride | Camostat mesylate | 2,3-Butanedione 2-Monoxime | 4-Hydroxyacetophenone | FOY 251 | Shz 1 | Benzamidine hydrochloride

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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