MS4078 NEW
| Price | $44 | $64 | $97 |
| Package | 1mg | 2mg | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-02 |
Product Details
| Product Name: MS4078 | CAS No.: 2229036-62-6 |
| Purity: 98.74% | Supply Ability: 10g |
| Release date: 2026/06/02 |
Product Introduction
Bioactivity
| Name | MS4078 |
| Description | MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19?nM for binding affinity to ALK. |
| In vitro | MS4078 effectively inhibits cancer cell proliferation by inducing ALK protein degradation via a cereblon and proteasome-dependent mechanism. In SU-DHL-1 cells, it shows an IC50 of 33 nM, and potently reduces ALK fusion protein levels, inhibits ALK auto-phosphorylation, and downstream STAT3 phosphorylation in a concentration-dependent manner. It specifically reduces NPM-ALK protein levels in SU-DHL-1 cells (DC50 of 11 nM) and EML4-ALK protein levels in NCI-H2228 cells (DC50 of 59 nM). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : < 10 mg/mL (10.94 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. DMSO : 150 mg/mL (164.03 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (10.94 mM), Solution. |
| Keywords | PROTACs | MS-4078 | MS4078 | MS 4078 | Inhibitor | inhibit | Cluster of differentiation 246 | Cereblon | CD246 | Anaplastic lymphoma kinase (ALK) | Anaplastic lymphoma kinase | ALK tyrosine kinase receptor | ALK |
| Inhibitors Related | Alectinib | ALKBH5-IN-5 | Alectinib hydrochloride | SB-431542 | RepSox | Bavdegalutamide | Crizotinib | dBET6 | ARV-825 | Brigatinib | Vepdegestrant | A 83-01 |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Kinase Inhibitor Library | Multi-Target Compound Library | Angiogenesis related Compound Library | Post-Translational Modification Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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WUHAN FORTUNA CHEMICAL CO., LTD
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2026-06-05 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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