MY-1B NEW
| Price | $129 | $321 | $511 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-15 |
Product Details
| Product Name: MY-1B | CAS No.: 2929308-79-0 |
| Purity: 99.81% | Supply Ability: 10g |
| Release date: 2026/05/15 |
Product Introduction
Bioactivity
| Name | MY-1B |
| Description | MY-1B is a covalent inhibitor and an inhibitor of RNA methyltransferase NSUN2 (IC50 = 1.3 μM), featuring stereoselectivity, covalent binding to C271 of NSUN2, and the ability to target PSME1, disrupt proteasome regulatory complexes, and downregulate presentation of specific MHC-I subtypes. |
| In vitro | Methods: The inhibitory effect of MY-1B (2.5–20 μM, 0–2000 seconds) on NSUN2 methyltransferase activity was determined by enzyme kinetic assays. Results: MY-1B inhibited NSUN2 activity with a Kinact/Ki value of 67 ± 15 M?1.[1] Methods: In HEK293T cells, MY-1B (6.25–100 μM) was used to treat for 2 hours to assess binding to C1113 of DCAF1 protein. Results: MY-1B served as a stereo- and site-selective covalent ligand for C1113 of DCAF1.[2] Methods: In human prostate cancer cell lines, MY-1B (5 or 20 μM) was used to treat for 3 hours to assess binding to C271 of NSUN2 protein. Results: MY-1B bound to C271 of NSUN2 with stereoselectivity and site specificity.[3] |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (183.36 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (7.56 mM), Sonication is recommended. |
| Inhibitors Related | Decitabine | GSK-3484862 | Levetiracetam | Dihydro-5-azacytidine FA | 5-Azacytidine | CBHcy | SW155246 | Procainamide hydrochloride | Zebularine | γ-Oryzanol | TFMB-(S)-2-HG | Hinokitiol |
| Related Compound Libraries | Bioactive Compound Library | Epigenetics Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | High-Efficiency Gene Editing Small Molecule Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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