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Postion:Product Catalog >Organic Chemistry>Carboxylic acids and derivatives>Carboxylic acid esters and derivatives>Mycophenolate Mofetil
Mycophenolate Mofetil
  • Mycophenolate Mofetil

Mycophenolate Mofetil NEW

Price $41 $63
Package 50mg 100mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: Mycophenolate Mofetil CAS No.: 128794-94-5
Purity: 99.85% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameMycophenolate Mofetil
DescriptionMycophenolate Mofetil (TM-MMF), an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrogenase (IMPDH).
In vitroAs an ester prodrug of the active immunosuppressant mycophenolic acid, Mycophenolate mofetil (10 μg/mL) significantly induces apoptosis in microglial cell cultures and increases the number of apoptotic cells due to activated caspase-3 immunoreactivity. At a concentration of 1 μg/mL, Mycophenolate mofetil also potently inhibits the proliferation of astrocytes and microglia. Recent studies have shown that following neuronal injury, Mycophenolate mofetil significantly reduces the extent of neuronal cell death in organotypic hippocampal slice cultures in a time-dependent manner. Mycophenolic acid inhibits the activity of both type I/II isocitrate dehydrogenase in a non-competitive, reversible, and selective manner, with IC50 values of 39 nM and 27 nM, respectively. Moreover, it concentration-dependently inhibits the proliferation of ConA-stimulated T cells (IC50 = 100 nM), lipopolysaccharide-stimulated B cells (IC50 = 120 nM), and alloantigen-specific T cell proliferation (IC50 = 51 nM).
In vivoAt a high concentration of 10 μg/mL, Mycophenolate mofetil induces significant apoptosis in microglial cell cultures and increases the number of apoptotic cells exhibiting elevated levels of activated caspase-3 immunoreactivity. Furthermore, at 1 μg/mL, it strongly inhibits the proliferation of microglia and astrocytes. Recent studies have demonstrated that Mycophenolate mofetil significantly attenuates the extent of neuronal death in organotypic hippocampal slice cultures following neuronal injury in a time-dependent manner. Mycophenolate mofetil, an active immunosuppressive ester prodrug of mycophenolic acid, exhibits non-competitive, selective, and reversible inhibition of inosine monophosphate dehydrogenase type I/II, with IC50 values of 39 nM and 27 nM, respectively. Moreover, mycophenolic acid, the immunosuppressive agent, also inhibits the proliferation of T cells stimulated by ConA, B cells stimulated by lipopolysaccharide, and allospecific T cells in a concentration-dependent manner, with IC50 of 100 nM, 120 nM, and 51 nM, respectively.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 127 mg/mL (292.97 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (9.23 mM), Sonication is recommended.
KeywordsRS-61443 | RS61443 | Mycophenolate Mofetil | Inhibitor | inhibit | IMPDH | DrugMetabolite | Drug Metabolite | Apoptosis
Inhibitors RelatedSucrose | Neomycin sulfate | Aceglutamide | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Glycerol | Thymidine | Dimethyl sulfoxide | Gluconate Calcium | Sodium bicarbonate | DL-Lysine
Related Compound LibrariesFailed Clinical Trials Compound Library | Bioactive Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | Microbial Natural Product Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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