Product Details
| Product Name:
Namitecan |
CAS No.:
372105-27-6 |
| Supply Ability:
10g |
Release date:
2026/04/21 |
Product Introduction
Bioactivity
| Name | Namitecan |
| Description | Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property. |
| In vitro | Namitecan decreases a dose-dependent decrease in EGFR expression in the different cell lines[1]. Namitecan and cetuximab cooperate in inhibiting EGFR expression. ST1968 causes a comparable level of apoptosis in A431 and A431/TPT cells (IC50: 0.21 and 0.29 μM)[2]. |
| In vivo | Namitecan (10 mg/kg) combined with cetuximab (1 mg/mouse) demonstrates synergistic antitumor effects in SCC models, dependent on the EGFR gene copy number[1]. ST1968 (25 mg/kg) is associated with tolerable body weight loss and no fatal toxicity, achieving a 100% complete response rate in mice with the A431 tumor, and maintaining significant efficacy in topotecan-resistant tumors[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Topoisomerase I | ST1968 | ST 1968 | Namitecan |
| Inhibitors Related | Ciprofloxacin hydrochloride monohydrate | Berberine chloride | EIDD-1931 | Levofloxacin hydrochloride | Norfloxacin | Anthraquinone | Prulifloxacin | 1,4-Naphthoquinone | Ofloxacin | Levofloxacin | 3-Hydroxypyridine | Etoposide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Suppliers |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States