Nefazodone NEW
| Price | $35 | $54 |
| Package | 2mg | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-26 |
Product Details
| Product Name: Nefazodone | CAS No.: 83366-66-9 |
| Purity: 99.85% | Supply Ability: 10g |
| Release date: 2026/05/26 |
Product Introduction
Bioactivity
| Name | Nefazodone |
| Description | Nefazodone (Nefadar) is an oral antidepressant that is an antagonist of postsynaptic 5-HT 2A receptor and 5-HT 2C receptor, and also inhibits the reuptake of norepinephrine, dopamine, and serotonin (SNDRI). |
| In vitro | Nefazodone inhibited mitochondrial respiration in isolated rat liver mitochondria and in intact HepG2 cells, where this was accompanied by simultaneous acceleration of glycolysis. At the concentration of 200 μM over 24 hours, nefazodone depletes 100% of ATP in both glucose and galactose-grown HepG2 cells. At the concentrations of 6.25, 12.5, and 25 μM within 120 minutes, nefazodone suppresses oxygen consumption in HepG2 cells, indicating strong mitochondrial respiratory inhibition in HepG2 cells. [1] |
| In vivo | Nefazodone (10?mg/kg/day, s.c) demonstrated immunoprotective effects in mice subjected to chronic auditory stress by partially reversing stress-induced reductions in thymus and spleen cellularity, peripheral T-lymphocyte levels, lymphocyte proliferative response to concanavalin A, and phagocytic activity (assessed via zymosan and carbon clearance tests). Nefazodone had no significant impact on these immune parameters in unstressed mice, indicating a selective protective role under stress conditions. [2] |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : < 1 mg/mL (insoluble) DMSO : 125 mg/mL (265.95 mM), Sonication is recommended. |
| Keywords | Nefazodone |
| Inhibitors Related | Oxadiazon | Musk ketone | Alverine citrate | Dapoxetine hydrochloride | Hexamethonium Bromide | Ipriflavone | Benzyl alcohol | Sudan IV | 1,8-Cineole | Naringin | Dibenzothiophene | Cinchonidine |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | Neuronal Signaling Compound Library | Drug-induced Liver Injury (DILI) Compound Library | Toxic Compound Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | GPCR Compound Library | Serotonin Receptor-Targeted Compound Library | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $39.00 |
VIP6Y
|
TargetMol Chemicals Inc.
|
2026-06-02 | |
|
VIP7Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2025-12-24 | ||
| $1.00 |
VIP8Y
|
Career Henan Chemical Co
|
2019-07-06 | |
| $1.00 |
VIP8Y
|
Career Henan Chemical Co
|
2019-07-06 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
INQUIRY