Product Details
| Product Name:
Neriifolin |
CAS No.:
466-07-9 |
| Purity:
98.59% |
Supply Ability:
10g |
| Release date:
2026/04/21 |
Product Introduction
Bioactivity
| Name | Neriifolin |
| Description | Neriifolin (17β-Neriifolin), a cardiac glycoside extracted from the unripe fruit of Cerbera manghas, is a Na+K+-ATPase inhibitor with anticancer activity that inhibits cell proliferation by suppressing HOXA9-dependent gene expression and inducing apoptosis in the human acute myeloid cell line, THP-1. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells and can be used in prostate cancer research. |
| In vitro | Treatment of Neriifolin at a concentration of 0.1 μg/mL for 48 hours was able to cause apoptosis of HepG2 cells. In addition, Neriifolin significantly reduced the viability of HepG2 cells after 72 hours of treatment at concentrations ranging from 0 to 8 μg/mL. The compound also caused cell cycle arrest in the S and G2/M phases, further promoting apoptosis in HepG2 cells. When HepG2 cells were stimulated by Neriifolin, caspase-3, caspase-8, and caspase-9 were activated, while the expression of Fas and FasL proteins was upregulated. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (149.62 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (6.17 mM), Sonication is recommended.
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| Keywords | Na+/K+ ATPase | Autophagy | Apoptosis |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Urea | Tamoxifen | Guanidine hydrochloride | Hydroxychloroquine | Metronidazole | Formamide | Paeonol | Naringin | Alginic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Shaanxi Haibo Biotechnology Co., Ltd
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2023-08-25 |
United States