Nicotinamide N-oxide NEW
| Price | $33 | $48 |
| Package | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-04-29 |
Product Details
| Product Name: Nicotinamide N-oxide | CAS No.: 1986-81-8 |
| Purity: 99.9% | Supply Ability: 10g |
| Release date: 2025/04/29 |
Product Introduction
Bioactivity
| Name | Nicotinamide N-oxide |
| Description | Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase. |
| In vitro | Nicotinamide, a vitamin B3 variant, serves as a precursor to nicotinamide adenine dinucleotide, crucial for oxidative phosphorylation and dehydrogenase cofactor roles. It undergoes metabolism via two pathways: initial methylation by nicotinamide N-methyltransferase, followed by aldehyde oxidase oxidation, and direct oxidation to nicotinamide N-oxide. Studies have introduced a range of nicotinamide N-oxides as innovative, effective CXCR2 receptor antagonists. Specifically, Compound 1 effectively inhibits neutrophil chemotaxis (IC50=10 nM), whereas Compound 2 selectively blocks IL-8 binding (IC50=110 nM) and also significantly hampers neutrophil chemotaxis (IC50=170 nM). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 3.85 mg/mL (27.85 mM), Sonication is recommended. H2O : Limited solubility |
| Keywords | Nicotinamide N-oxide | Nicotinamide Noxide | Nicotinamide N oxide | Nicotinamide | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | DrugMetabolite | Drug Metabolite | CXCR | CXC chemokine receptors | c-Myc | cMyc |
| Inhibitors Related | Sucrose | Acetaminophen | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Gut Microbial Metabolite Library | GPCR Compound Library | Food as Medicine Compound Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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