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Postion:Product Catalog >API>Circulatory system drugs>Calcium channel blockers>Nilvadipine
Nilvadipine
  • Nilvadipine

Nilvadipine NEW

Price $30 $32 $37
Package 10mg 25mg 50mg
Supply Ability: 10g
Update Time: 2026-04-22

Product Details

Product Name: Nilvadipine CAS No.: 75530-68-6
Purity: 99.93% Supply Ability: 10g
Release date: 2026/04/22

Product Introduction

Bioactivity

NameNilvadipine
DescriptionNilvadipine (FK235), a calcium channel blocker (CCB), is utilized for treatment of hypertension.
In vitroIn RCS rats' retinas, Nilvadipine significantly increased the expression of rhodopsin kinase and αA-crystallin, while it decreased the expression of caspase-1 and caspase-2. It also entirely inhibited arterial vasoactivity induced by Abeta in rat aortas and human brains. Furthermore, Nilvadipine (0.4 mg/kg i.v. and 2 mg/kg p.o.) was able to reduce paw edema induced by localized ischemia in mice.
In vivoIn perfused hydronephrotic kidneys, Nilvadipine effectively dilates both afferent and efferent arterioles, enhancing renal blood flow. Moreover, in rat aortic smooth muscle cells (IC50=0.1 nM), Nilvadipine inhibits the chemotactic responses to interleukin-1, leukotriene B4, and platelet-derived growth factor.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationEthanol : 19.3 mg/mL (50.08 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.5 mg/mL (6.49 mM), Sonication is recommended.
DMSO : 55 mg/mL (142.72 mM), Sonication is recommended.
KeywordsNilvadipine | Inhibitor | inhibit | FR-34235 | FR 34235 | FK-235 | FK 235 | CalciumChannel | Calcium Channel | Ca2+ channels | Ca channels | ARC-029 | ARC 029
Inhibitors RelatedQuadrol | Tricaine methanesulfonate | Nisoldipine | 2,4,6-Tri-tert-butylphenol | Chlorocresol | L-Ascorbic acid | L-Phenylalanine | L-Ascorbic acid sodium salt | 2-Nitrobenzoic acid | Magnesium Chloride Hexahydrate | Magnesium sulfate | Cinchonine
Related Compound LibrariesPain-Related Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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