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Postion:Product Catalog >Ningetinib
Ningetinib
  • Ningetinib

Ningetinib NEW

Price $65 $92 $188
Package 5mg 10mg 25mg
Supply Ability: 10g
Update Time: 2026-06-01

Product Details

Product Name: Ningetinib CAS No.: 1394820-69-9
Purity: 99.98% Supply Ability: 10g
Release date: 2026/06/01

Product Introduction

Bioactivity

NameNingetinib
DescriptionNingetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
In vitroIn cell-based functional assays, Ningetinib inhibits VEGF and HGF-stimulated HUVEC proliferation and microvascular angiogenesis in rat aortic rings with IC50 values of 6.3 and 8.6 nM, respectively.
In vivoIn the orthotopic U87MG human glioblastoma xenograft model, Ningetinib prolongs the median survival time and yields a significant increase in life-span value (ILS=32%) at an oral dose of 20 mg/kg/day (dosed 21 days) versus the vehicle-treated group. When single dosed orally (3 mg/kg) to U87MG tumor-bearing nude mice, Ningetinib potently inhibits the phosphorylation of c-Met and its downstream signaling kinases AKT and ERK1/2 for up to 6 hours in tumor tissues.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 15 mg/mL (26.95 mM), Sonication is recommended.
KeywordsVEGFR2 | VEGFR | Vascular endothelial growth factor receptor | Tyro3 | TAMReceptor | TAM Receptor | Ningetinib | Mer | Inhibitor | inhibit | HGFR | CT053 | CT 053 | c-Met/HGFR | cMet/HGFR | c-Met | cMet | Axl
Inhibitors RelatedRibociclib | Bemcentinib | Gilteritinib | Decanoic Acid | Sorafenib | glycine | Nintedanib esylate | Afatinib | Chloramphenicol | Bacitracin Zinc | Lenvatinib | Pazopanib
Related Compound LibrariesFailed Clinical Trials Compound Library | Bioactive Compound Library | Cytokine Inhibitor Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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