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Postion:Product Catalog >NKH477
NKH477
  • NKH477

NKH477 NEW

Price $149
Package 2mg
Supply Ability: 10g
Update Time: 2025-08-22

Product Details

Product Name: NKH477 CAS No.: 138605-00-2
Purity: 98.00% Supply Ability: 10g
Release date: 2025/08/22

Product Introduction

Bioactivity

NameNKH477
DescriptionNKH477 (Colforsin dapropate hydrochloride) is a derivative of forskolin with antidepressant activity. It inhibits ACh-induced Ca2+ mobilization by acting on ionomycin-sensitive storage sites. NKH477 is an adenylyl cyclase activator with bronchodilatory effects, inhibiting the production of CTL, T-cell proliferation in mixed lymphocyte reactions (MLR), as well as IL-2 production and mitogen responses.
In vitroNKH477 (0.1-1.0 μM) inhibits ACh induced contraction in a concentration-dependent manner by attenuating ACh induced Ca2 + mobilization and reducing the sensitivity of the contractile mechanism to Ca2 +. [1]
In vivoIn experimental dogs, intravenous administration of NKH477 (1-30 μg/kg) resulted in an increase in left ventricular dP/dtmax, coronary and femoral blood flow, heart rate, and myocardial oxygen consumption, as well as a decrease in blood pressure in anesthetized dogs. NKH477 is a useful insulin dilator for the treatment of heart failure. [2]
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 80 mg/mL (146.5 mM), Sonication is recommended.
H2O : 10 mg/mL (18.31 mM), Sonication is recommended.
KeywordsNKH-477 | NKH477 | Adenylate Cyclase
Inhibitors RelatedAdiphenine hydrochloride | Nanofin | Forskolin | Pilocarpine Hydrochloride | Clozapine N-Oxide | Pilocarpine nitrate | Urethane | Ribavirin | D-Menthol | Amitriptyline hydrochloride | Choline chloride | Propoxur

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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