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Postion:Product Catalog >NMac1
NMac1
  • NMac1

NMac1 NEW

Price $1670 $2230
Package 25mg 50mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: NMac1 CAS No.: 1332290-68-2
Purity: 99.89% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameNMac1
DescriptionNMac1 (Nm23 activator 1) is a natural compound, cassumunene, derived from Zingiber cassumunar Roxb. and traditionally used as an anti-inflammatory agent in East Asia. NMac1 exhibits anti-metastatic potential by directly interacting with the C-terminal of Nm23-H1, activating its NDP kinase (NDPK) enzymatic activity in vitro. NMac1 inhibits breast cancer metastasis in vivo.
In vitroNMac1 is a potent activator of NDPK protein, activating NDPK activity of recombinant Nm23-H1 in a dose-dependent manner with an EC50 of 10.7 μM. The morphological changes observed in MDA-MB-231 cells after treatment with NMac1 (25 μM) included substantial changes in the original height mesenchymal type (with a large number of folds) to a non-metastatic form with reduced folds and increased cell coverage. NMac1 significantly reduced invasion and migration of MDA-MB-231 cells in a dose-dependent manner without affecting their proliferation. [1]
In vivoIn NOD/SCID mice injected in situ with MDA-MB-231-LUS-D3H2LN cells, treatment with NMac1 (10 mg/Kg, 3 weeks) significantly inhibited breast cancer metastasis without affecting primary tumor size. [1]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
KeywordsNMac1 | Irinotecan Carboxylate Sodium Salt
Inhibitors RelatedEthoxyquin | Kaolin | Allopurinol | Urea | Imeglimin hydrochloride | Ethyl linoleate | Magnesium acetate tetrahydrate | L-Cystine | Gluconate Calcium | Dimethyl phthalate | Daraxonrasib | Chitosan oligosaccharide
Related Compound LibrariesPI3K-AKT-mTOR Compound Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | MAPK Inhibitor Library

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

Recommended supplier

Product name Price   Suppliers Update time
Anhui Ruihan Technology Co., Ltd
2023-08-21

TargetMol Chemicals Inc.

2YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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