Nosiheptide NEW
| Price | $35 | $81 | $147 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-14 |
Product Details
| Product Name: Nosiheptide | CAS No.: 56377-79-8 |
| Purity: 95.37% | Supply Ability: 10g |
| Release date: 2026/07/14 |
Product Introduction
Bioactivity
| Name | Nosiheptide |
| Description | Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by *Streptomyces actuosus*, is a potent feed additive that promotes animal growth by inhibiting bacterial protein synthesis. It is characterized by an indole side ring system and regiospecific hydroxyl groups on its macrocyclic core. |
| In vitro | Nosiheptide demonstrates non-toxic behavior towards mammalian cells at concentrations greater than 100 times the minimum inhibitory concentration (MIC) and retains its effectiveness against Staphylococcus aureus in the presence of 20% human serum. It is particularly potent against Enterococcus spp., the hypervirulent BI strain of Clostridium difficile, and displays remarkable activity against all tested strains of Staphylococcus aureus, including those resistant to multiple drugs (MIC values ≤ 0.25 mg/L). Additionally, Nosiheptide exhibits a significantly extended post-antibiotic effect against both healthcare- and community-associated Staphylococcus aureus when compared to vancomycin. Through time-kill studies, Nosiheptide has been found to quickly eliminate Staphylococcus aureus in a concentration- and time-dependent manner, achieving a near 2-log reduction at 6 hours with a concentration 10 times the MIC [1]. |
| In vivo | Nosiheptide (20 mg/kg; intraperitoneal injection; administered at 1 and 8 hours post-infection; female CD1 mice) significantly protects against mortality, with all 10 treated mice surviving by day 3, compared to 6 out of 10 control mice dying on day 1[1]. |
| Storage | Keep away from moisture,Store at low temperature,Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : 5 mg/mL (4.09 mM), Suspension. DMSO : 50 mg/mL (40.9 mM), Sonication is recommended. |
| Keywords | RP-9671 | RP9671 | Nosiheptide | Inhibitor | inhibit | Bacterial | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | BES |
| Related Compound Libraries | Macrocyclic Compound Library | Bioactive Compound Library | Antibiotics Library | Microbial Natural Product Library | Anti-Bacterial Compound Library | NO PAINS Compound Library | Covalent Natural Product Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Anti-Infection Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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