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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>NS11394
NS11394
  • NS11394

NS11394 NEW

Price $29 $46 $73
Package 2mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: NS11394 CAS No.: 951650-22-9
Purity: 99.44% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameNS11394
DescriptionNS11394 is a effective and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of α(5) > α(3) > α(2) > α(1) at GABA(A) alpha subunit-containing receptors.
Kinase AssayInhibition of FLT3 autophosphorylation: To measure inhibition of FLT3 autophosphorylation, MV4-11 or RS4;11 cells are cultured in low serum media (0.5% FBS) overnight and seeded at a density of 400 000 cells per well in a 96-well plate the following day. The cells are incubated with different concentrations of AC220 for 2 hours at 37 °C. To induce FLT3 autophosphorylation in RS4;11 cells, 100 ng/mL FLT3 ligand is added for 15 minutes after the 2-hour AC220 incubation. Cell lysates are prepared and incubated in 96-well plates precoated with a total FLT3 capture antibody. The coated plates are incubated with either a biotinylated antibody against FLT3 to detect total FLT3 or an antibody against phosphotyrosines to detect FLT3 autophosphorylation. In both cases, a SULFO-tagged streptavidin secondary antibody is used for electrochemiluminescence detection on the Meso Scale Discovery platform. The concentration of AC220 that inhibits FLT3-ITD or TLT3-WT autophosphorylation by 50% represents IC50 value
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.66 mM), Sonication is recommended.
DMSO : 60 mg/mL (169.77 mM), Sonication is recommended.
Keywordsγ-Aminobutyric acid Receptor | pinal | pain | NS-11394 | NS11394 | neuropathi | Inhibitor | inhibit | inflammatory | Gamma-aminobutyric acid Receptor | GABAReceptor | GABAA | GABA Receptor | Freund's | electrophysiological | cord | Complete | Anxiety | adjuvant
Inhibitors RelatedValproic acid sodium salt | p-Hydroxybenzaldehyde | Urethane | Baicalin | Imidazoleacetic acid hydrochloride | Penicillin G sodium salt | Valproic Acid | Methyl eugenol | (-)-α-Pinene | Nipecotic acid | Dihydromyricetin | Methionine
Related Compound LibrariesAnti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | NO PAINS Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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