NSC 23766 NEW
| Price | $49 |
| Package | 2mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: NSC 23766 | CAS No.: 733767-34-5 |
| Purity: 99.49% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | NSC 23766 |
| Description | NSC 23766 is a Rac1 GTPase inhibitor that inhibits Rac1 activation by targeting guanine nucleotide exchange factors (GEFs), while it has no inhibitory effect on the closely related targets Cdc42 and RhoA, affecting the cell cycle and inhibiting cell proliferation in a dose-dependent manner. It also regulates endothelial NO synthase expression and endothelial function, and inhibits platelet aggregation and γ-secretase activity.NSC23766 competitively inhibits M2 muscarinic acetylcholine receptor (M2 mAChR)-induced Rac1 activation in neonatal rat cardiomyocytes. |
| In vitro | Treatment of oocytes with NSC 23766 (200 μM) increased the percentage of oocytes with abnormal spindle morphology and significantly decreased the expression of p-MAPK protein. [2] |
| In vivo | Treatment of NOD mice with NSC 23766 (2.5 mg/kg/day, intraperitoneal injection) significantly slowed the onset of spontaneous diabetes in NOD mice and had no significant effect on the growth (body weight) of the mice. [1] |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (7.83 mM), Sonication is recommended. DMSO : 80 mg/mL (189.76 mM), Sonication is recommended. |
| Keywords | NSC-23766 | NSC 23766 |
| Inhibitors Related | Adiphenine hydrochloride | Levamisole hydrochloride | RMC-9805 | Urethane | Hexamethonium Bromide | Ribavirin | Adenine | Mitotane | Sotorasib | N,N-Dicyclohexylcarbodiimide | Arecoline | Daraxonrasib |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Multi-Target Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | GPCR Compound Library | Anti-Cancer Compound Library | MAPK Inhibitor Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36 Washington Street, Wellesley Hill, USA
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